HCID 44578670, compound → Isonicotinamide

Participants

Reaction Steps

A solution of 2-chloro-N-(4′-{[(cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)isonicotinamide (50 mg, 0.12 mmol) in diethylamine (2 ml) was heated at 80° C. for 48 h and then at 110° C. for 84 h in a sealed tube. The reaction was concentrated under vacuum, the residue triturated with water and purified by preparative HPLC. The solvent was evaporated under vacuum to give N-(4′-{[(cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)-2-diethylamino)isonicotinamide. NMR; δH [2H6]—DMSO 10.27,(1H, s), 8.62,(1H, t), 8.19,(1H, d), 7.93,(2H, d), 7.69,(1H, dd), 7.65,(1H, d), 7.44,(2H, d), 7.30,(1H, d), 0.43,(4H, m), 0.24,(2H, m). LCMS: retention time 3.09 min, MH+457.

Provenance & Evidence