2-Methylpyrrolidine → HCID 69202406, compound

Participants

Reaction Steps

A solution of 2-chloro-N-(4′-{[(cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)isonicotinamide (50 mg, 0.12 mmol) in 2-methylpyrrolidine (1 ml) was heated at 120° C. for 18 h in a sealed tube. The reaction was concentrated under vacuum, the residue triturated with water to give N-(4′-{[(cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)-2-(2-methylpyrrolidin-1-yl)isonicotinamide (35 mg). NMR; δH [2H6]—DMSO 10.27,(1H, s), 8.62,(1H, t), 8.20,(1H, d), 7.93,(2H, d), 7.70,(1H, d), 7.66,(1H, s), 7.44,(2H, d), 7.30,(1H, d), LCMS: retention time 2.89 min, MH+469.

Provenance & Evidence