5-(Pyridin-2-yl)thiophene-2-carboxylic acid → HCID 69202963, compound

Participants

Reaction Steps

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)-5-(pyrid-2-yl)thiophene-2- carboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4-carboxamide and 5-(pyrid-2-yl)thiophene-2-carboxylic acid using method D. The product was further purified by preparative HPLC. NMR; δH [2H6]—DMSO 10.29,(1H, s), 8.63,(1H, t), 8.58,(1H, d), 8.02-7.99,(2H, m), 7.94,(2H, d), 7.90-7.86,(2H, m), 7.70,(1H, dd), 7.65,(1H, d), 7.46,(2H, d), 7.35,(1H, m), 7.30,(1H, d), 3.17,(2H, t), 2.21,(3H, s), 1.04,(1H, m), 0.43,(2H, m), 0.24,(2H, m). LCMS: retention time 3.60 min, MH+468.

Provenance & Evidence