2-(3-Pyridyl)thiazole-4-carboxylic acid → HCID 69203168, compound

HRID 2114118Notes

Reaction equation

HRID 2114118 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:21])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH:18]3[CH2:20][CH2:19]3)=[O:15])=[CH:10][CH:9]=2)[CH:7]=1.[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]2[S:29][CH:30]=[C:31]([C:33](O)=[O:34])[N:32]=2)[CH:23]=1>>[CH:18]1([CH2:17][NH:16][C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]3[C:5]([CH3:21])=[CH:4][CH:3]=[C:2]([NH:1][C:33]([C:31]4[N:32]=[C:28]([C:24]5[CH:23]=[N:22][CH:27]=[CH:26][CH:25]=5)[S:29][CH:30]=4)=[O:34])[CH:7]=3)=[CH:9][CH:10]=2)=[O:15])[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 7365132-(3-Pyridyl)thiazole-4-carboxylic acidHCID 113004885'-amino-N-(cyclopropylmethyl)-2'-methyl-1,1'-biphenyl-4-carboxamide

Product 1

HCID 69203168HCID 69203168, compound

Procedure

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)-2-(pyrid-3-yl)thiazole-4-carboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4-carboxamide and 2-(pyrid-3-yl)thiazole-4-carboxylic acid using method D. NMR; δH CDCl3 9.26,(1H, b), 9.24,(1H, d), 8.73,(1H, d), 8.28,(2H, m), 7.85,(2H, d), 7.72,(1H, dd), 7.60,(1H, d), 7.47-7.44,(3H, m), 7.32,(1H, d), 6.29,(1H, t), 3.36,(2H, m), 2.26,(3H, s), 1.10,(1H, m), 0.59,(2H, m), 0.31,(2H, m). LCMS: retention time 3.36 min, MH+469.

Sources & evidence

ORD record
ord-5f93d83c550e4dadacfa8566b3cc33b1
Source dataset
uspto-grants-2008_10
Patent number
US07432289B2

Reaction notes

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