1,2-Oxazole-5-carboxylic acid → HCID 44578461, compound

HRID 2114130Notes

Reaction equation

HRID 2114130 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:21])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH:18]3[CH2:20][CH2:19]3)=[O:15])=[CH:10][CH:9]=2)[CH:7]=1.[O:22]1[C:26]([C:27](O)=[O:28])=[CH:25][CH:24]=[N:23]1>>[CH:18]1([CH2:17][NH:16][C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]3[C:5]([CH3:21])=[CH:4][CH:3]=[C:2]([NH:1][C:27]([C:26]4[O:22][N:23]=[CH:24][CH:25]=4)=[O:28])[CH:7]=3)=[CH:9][CH:10]=2)=[O:15])[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 20605991,2-Oxazole-5-carboxylic acidHCID 113004885'-amino-N-(cyclopropylmethyl)-2'-methyl-1,1'-biphenyl-4-carboxamide

Product 1

HCID 44578461HCID 44578461, compound

Procedure

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)isoxazole-5-carboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1,1′-biphenyl-4- carboxamide and isoxazole-5-carboxylic acid using method D. NMR; δH [2H6] —DMSO 10.75, (1H, s), 8.81,(1H, d), 8.62,(1H, t), 7.93,(2H, d), 7.70,(1H, dd), 7.66,(1H, d), 7.44,(2H, d), 7.32,(1H, d), 7.24,(1H, d), 3.16,(2H, t), 2.21,(3H, s), 1.04,(1H, m), 0.43,(2H, m), 0.24,(2H, m). LCMS: retention time 3.17 min, MH+376.

Sources & evidence

ORD record
ord-5f034c0eb59244139f5cd29628198f73
Source dataset
uspto-grants-2008_10
Patent number
US07432289B2

Reaction notes

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