Sodium Carbonate → N-(3-Bromo-4-chlorophenyl)-3-furamide

Participants

Reaction Steps

3-Bromo-4-chloroaniline (150 mg), 3-furoylchloride (0.15 ml) and sodium carbonate (1 g) were stirred for 18 hours at room temperature in DCM (15 ml). The reaction was filtered, the residue washed with DCM and the combined DCM fractions reduced to dryness under vacuum to give N-(3-bromo-4-chlorophenyl)-3-furamide. NMR; δH [2H6]—DMSO 10.13,(1H, s), 8.38,(1H, s), 8.20,(1H, d), 7.81,(1H, m), 7.73,(1H, dd), 7.59,(1H, d), 6.97,(1H, m).

Provenance & Evidence