Dimethylformamide → 4'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carbonyl chloride

Participants

Reaction Steps

Oxalyl chloride (2.43 mL) was added dropwise to a mixture of 4′-trifluoromethylbiphenyl-2-carboxylic acid (5.06 g), dimethylformamide (catakytic amount) and methylene chloride (30 mL) under ice-cooling. The reaction mixture was stirred at room temperature for 100 minutes, and concentrated to remove the solvent. The residue was evaporated azeotropically together with toluene, and dried in vacuo to give the title compound (5.40 g).

Provenance & Evidence