Tetrahydrofuran → HCID 58706399, compound

Participants

Reaction Steps

To a solution of 4′-trifluoromethylbiphenyl-2-carboxylic acid (4-benzyloxy-2-dimethylcarbamoyl-5-fluorophenyl)amide (1.48 g) in a mixed solvent of THF (10 mL) and methanol (10 mL) was added 7.5% palladium carbon (200 mg). The mixture was stirred at room temperature for 3 hours under hydrogen atmosphere. The reaction solution was filtered through a celite to remove the catalyst, and the filtrate was concentrated to give 4′-trifluoromethylbiphenyl-2-carboxylic acid (2-dimethylcarbamoyl-5-fluoro-4-hydroxyphenyl)amide (1.09 g).

Provenance & Evidence