Sodium Iodide → HCID 23130312, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4′-trifluoromethylbiphenyl-2-carboxylic acid {4-benzyloxy-2-[(2-chloroacetyl)isopropylamino]phenyl}amide (134 mg) in DMF (2 mL) were added potassium carbonate (48 mg) and sodium iodide (one spatula), and he mixture was stirred at 80° C. for 2 hours. The reaction solution was allowed to stand for cooling to room temperature, and diluted with ethyl acetate. The extract was washed with water and saturated brine, dried over sodium sulfate and concentrated. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=3:1) to give 7-benzyloxy-1-isopropyl-4-(4′-trifluoromethylbiphenyl-2-carbonyl)-3,4-dihydro-1H-quinoxalin-2-one (118 mg).

Provenance & Evidence