{3-Dimethylcarbamoyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]phenoxy}acetic acid benzyl ester → {3-Dimethylcarbamoyl-4-[(4'-trifluoromethylbiphenyl-2-carbonyl)amino]phenoxy}acetic acid

Participants

Reaction Steps

{3-Dimethylcarbamoyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenoxy}acetic acid benzyl ester (260 mg) was dissolved in ethyl acetate (5 mL), and thereto was added 7.5% palladium carbon (250 mg). The mixture was stirred for 1 hour under hydrogen atomosphere. The reaction solution was filtered through a Celite and the filtrate was concentrated to give {3-dimethylcarbamoyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenoxy}acetic acid (118 mg).

Provenance & Evidence