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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2114308Generated: October 30, 2026

Pyrazole → (r)-4-Bromo-5-(2-chlorobenzoylamino)-1-methyl-pyrazole-3-carboxylic acid (1,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1h-benzo[b][1,4]diazepin-3-yl)amide

https://huagongshe.com/reaction/2114308

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyrazoleHCID 1048—
Reactant2-Chlorobenzoyl chlorideHCID 69110—
ReactantHCID 178461679HCID 178461679—
ReactantHCID 178522629HCID 178522629—
Product(r)-4-Bromo-5-(2-chlorobenzoylamino)-1-methyl-pyrazole-3-carboxylic acid (1,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1h-benzo[b][1,4]diazepin-3-yl)amideHCID 59773391—

Reaction Steps

The pyrazole acid, prepared by coupling methyl ester 85 (Gen. Proc. 26) with 2-chlorobenzoyl chloride (21) followed by hydrolysis and bromination as shown in Gen. Proc. 8. was coupled to compound 92 (Procedure 27) using the method of Procedure 3.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07432379B2
Source datasetuspto-grants-2008_10
ORD IDord-f916f3bd86ef43c9848028e3ab5e0dd9
Source noteuspto-grants-2008_10