HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → 4-Methyl-5-(2-fluoro-benzoylamino)-1-phenyl-pyrazole-3-carboxylic acid[2-(3,4,5,6-tetrahydro-2h-[1,4']bipyridin-4-yl)-ethyl]amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | 2-Fluorobenzoyl chloride | HCID 9808 | — |
| Reactant | 2-Chlorobenzoyl chloride | HCID 69110 | — |
| Reactant | 2-[1-(Pyridin-4-yl)piperidin-4-yl]ethan-1-amine | HCID 22027821 | — |
| Reactant | Ethyl 3-cyano-3-methyl-2-oxopropanoate | HCID 59223396 | — |
| Reactant | 5-Amino-1-tert-butoxycarbonyl-3-methoxycarbonylpyrazole | HCID 59773335 | — |
| Reactant | ethyl 5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylate | HCID 68887576 | — |
| Product | 4-Methyl-5-(2-fluoro-benzoylamino)-1-phenyl-pyrazole-3-carboxylic acid[2-(3,4,5,6-tetrahydro-2h-[1,4']bipyridin-4-yl)-ethyl]amide | HCID 59773432 | — |
Reaction Steps
The pyrazole acid, prepared as described in Procedure 8 using 5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester (prepared as described in Procedure 41 using 3-cyano-3-methyl-2-oxopropanoic acid ethyl ester (U.S. Pat. No. 4,652,669)) in place of compound 20 and 2-fluorobenzoyl chloride in place compound 21, was coupled to 2-(3,4,5,6-tetrahydro-2H-[1,4′]bipyridin-4-yl)ethylamine (prepared as described in Procedure 14) using the method of Procedure 10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07432379B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-fe3d465c47654c4a9a52e67773118114 |
| Source note | uspto-grants-2008_10 |