HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → 4-Bromo-5-(2-chloro-benzoylamino)-1-methyl-pyrazole-3-carboxylic acid {2-[4-(4,5-dihydro-1h-imidazol-2-yl)-phenyl]ethyl}amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | 2-Chlorobenzoyl chloride | HCID 69110 | — |
| Reactant | 4-(2-Aminoethyl)benzonitrile | HCID 21912525 | — |
| Reactant | HCID 178461679 | HCID 178461679 | — |
| Product | 4-Bromo-5-(2-chloro-benzoylamino)-1-methyl-pyrazole-3-carboxylic acid {2-[4-(4,5-dihydro-1h-imidazol-2-yl)-phenyl]ethyl}amide | HCID 59773561 | — |
Reaction Steps
The pyrazole acid, prepared by coupling methyl ester 85 (Procedure 26) with 2-chlorobenzoyl chloride (21) followed by hydrolysis and bromination as shown in Procedure 8, was coupled to amine 169 (Procedure 34) using the method of Procedure 10. Formation of the amidine using the method of Procedure 33.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07432379B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-e69be65630d14143b64dcbb7b8392af9 |
| Source note | uspto-grants-2008_10 |