反应详情

To a cooled (0° C.) solution of morpholine (5.99 g, 68.7 mmol) in ether (20 mL) was added the solution of 1-(4-biphenylyl)-2-bromoethanone (9.47 g, 34.4 mmol) in a mixture of ether (100 mL) and dichloromethane (100 mL) dropwise at 0° C. After the addition was over, the reaction mixture was allowed to warm to room temperature and stirred at room temperature for 1 h. The mixture was concentrated under reduced pressure. The residue was dissolved in dichloromethane (150 mL) and extracted with 5% NaHCO3 (150 mL) and brine (100 mL). The organic layer was dried (MgSO4) and concentrated to give 9.70 g (100%) of the title compound as a white solid. MS (ES) m/e 281.2 [M+H]+.

1. additionAfter the addition
2. concentrationThe mixture was concentrated under reduced pressure
3. dissolutionThe residue was dissolved in dichloromethane (150 mL)
4. extractionextracted with 5% NaHCO3 (150 mL) and brine (100 mL)
5. dry with materialThe organic layer was dried (MgSO4)
6. concentrationconcentrated