1-Methyl-4-piperidone → HCID 59809555, compound

HRID 2114502Notes

Reaction equation

HRID 2114502 reaction equation
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Br:16])[CH:3]=1.NC1C=CC(C#N)=CC=1OC1C=CC=CC=1Br.[CH3:34][N:35]1[CH2:40][CH2:39][C:38](=O)[CH2:37][CH2:36]1.C(OC(N1CCC(=O)CC1)=O)(C)(C)C>>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH:38]2[CH2:39][CH2:40][N:35]([CH3:34])[CH2:36][CH2:37]2)=[C:4]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Br:16])[CH:3]=1

Participants

5

Reactant 4

HCID 740491-Methyl-4-piperidoneHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 59809535HCID 59809535, compound2×HCID 59809537HCID 59809537, compound

Product 1

HCID 59809555HCID 59809555, compound

Procedure

Using an adaptation of the method described in Procedure 3, substituting 4-bromo-2-(2-bromophenylsulfanyl)-aniline, 2e for 4-amino-3-(2-bromophenoxy)-benzonitrile, 2a, and 1-methylpiperidin-4-one for 4-oxo-piperidine-1-carboxylic acid tert-butyl ester, the title compound [4-bromo-2-(2-bromophenylsulfanyl)-phenyl]-(1-methyl-piperidin-4-yl)-amine, 3e was obtained.

Sources & evidence

ORD record
ord-40a3d0c5ef5d462eb88127ef848fbaab
Source dataset
uspto-grants-2008_10
Patent number
US07432257B2

Reaction notes

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