Methyl 2-hydroxy-3-nitrobenzoate → Methyl 3-amino-2-hydroxybenzoate

Participants

Reaction Steps

To a solution of 2-hydroxy-3-nitrobenzoic acid methyl ester (5 g, 25.4 mmol) in ethanol (40 mL) was added 10% palladium on carbon (0.5 g), and the mixture was hydrogenated for 2 h. The catalyst was removed via filtration and the solvent was removed via evaporation, yielding 4.17 g (88%) of title compound 3-amino-2-hydroxybenzoic acid methyl ester, 1l.

Provenance & Evidence