Ethanol → N-(7-(2-Hydroxyethyl)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide

HRID 211456Notes

Reaction equation

HRID 211456 reaction equation
[CH3:33][CH2:34][OH:35].[OH-:36].[OH-:38].[OH:1][CH:2]([CH2:3][OH:4])[c:5]1[c:6]([CH3:32])[c:7]([NH:24][C:25]([CH2:26][C:27]([CH3:28])([CH3:29])[CH3:30])=[O:31])[c:8]([CH3:23])[c:9]2[c:13]1[O:12][CH2:11][CH:10]2[c:14]1[cH:15][cH:16][c:17]([CH:20]([CH3:21])[CH3:22])[cH:18][cH:19]1.[Pd+2:37]>>[CH2:2]([CH2:3][OH:4])[c:5]1[c:6]([CH3:32])[c:7]([NH:24][C:25]([CH2:26][C:27]([CH3:28])([CH3:29])[CH3:30])=[O:31])[c:8]([CH3:23])[c:9]2[c:13]1[O:12][CH2:11][CH:10]2[c:14]1[cH:15][cH:16][c:17]([CH:20]([CH3:21])[CH3:22])[cH:18][cH:19]1

Participants

5

Reactant 4

HCID 702EthanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 23114170N-(7-(1,2-Dihydroxyethyl)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide

Product 1

HCID 23114309N-(7-(2-Hydroxyethyl)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide

Sources & evidence

ORD record
ord-5c1c3974369b4b4191354a016faee5d5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…