Potassium Hydroxide → HCID 68877139, compound

HRID 2114574Notes

Reaction equation

HRID 2114574 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:16]2[C:11](=[N:12][C:13](S(C)(=O)=O)=[N:14][C:15]=2[CH2:17][S:18]([N:21]([CH3:23])[CH3:22])(=[O:20])=[O:19])[N:10]([CH2:28][O:29][CH2:30][CH2:31][Si:32]([CH3:35])([CH3:34])[CH3:33])[N:9]=1.[F:36][C:37]1[CH:42]=[C:41]([F:43])[CH:40]=[CH:39][C:38]=1[OH:44].[OH-].[K+]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:16]2[C:11](=[N:12][C:13]([O:44][C:38]3[CH:39]=[CH:40][C:41]([F:43])=[CH:42][C:37]=3[F:36])=[N:14][C:15]=2[CH2:17][S:18]([N:21]([CH3:22])[CH3:23])(=[O:19])=[O:20])[N:10]([CH2:28][O:29][CH2:30][CH2:31][Si:32]([CH3:33])([CH3:35])[CH3:34])[N:9]=1

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 1230512,4-DifluorophenolHCID 68880122HCID 68880122, compound

Product 1

HCID 68877139HCID 68877139, compound

Procedure

C-[3-(2-Chloro-phenyl)-6-methylsulfonyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-N,N-dimethyl-methanesulfonamide (398 mg) was treated with 2,4-difluorophenol in the presence of KOH using the procedure of step 6 of Example 4 to afford 287 mg of C-[3-(2-Chloro-phenyl)-6-(2,4-difluoro-phenoxy)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-N,N-dimethyl-methanesulfonamide. Mass Spec. M+H=610.

Sources & evidence

ORD record
ord-57305c0473a1498fa38a4b32f5fd0732
Source dataset
uspto-grants-2008_10
Patent number
US07435731B2

Reaction notes

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