HCID 14425319, compound → HCID 11254741, compound

HRID 2114602Notes

Reaction equation

HRID 2114602 reaction equation
[CH2:1]([N:8]1[C:15]([NH2:16])=[CH:14][C:12](=[O:13])[N:11]([CH2:17][CH2:18][CH3:19])[C:9]1=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:20]([O-])=[O:21].[Na+]>C(O)(=O)C.C(O)C.O>[CH2:1]([N:8]1[C:15]([NH2:16])=[C:14]([N:20]=[O:21])[C:12](=[O:13])[N:11]([CH2:17][CH2:18][CH3:19])[C:9]1=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 2

HCID 14425319HCID 14425319, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 11254741HCID 11254741, compoundYield 85%

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

A solution of 1-benzyl-3-propyl-6-amino-uracil (6.2 mmol) in 80% acetic acid (15 mL) and 30 mL of ethanol, was stirred at 40° C. while a solution of NaNO2 (9.3 mmol) in water (10 mL) was added drop wise. The reaction was stirred for 30 minutes at 40° C. and after concentration the product precipitated from the reaction mixture and was collected by filtration. (Pink solid. Yield 85%).

Workup

  1. additionwas added drop wise
  2. concentrationafter concentration the product
  3. customprecipitated from the reaction mixture
  4. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-599634551fd941108b01ee2e5962aa90
Source dataset
uspto-grants-2008_10
Patent number
US07435740B2

Reaction notes

Loading…