Sodium Dithionite → HCID 11254336, compound

Participants

Reaction Steps

A solution of the nitroso-uracil derivative (from Example 4) (5 mmol) in water (25 mL) and 30% NH4OH (10 mL) was heated at 85° C. and sodium dithionite (15 mmol) was added in small portions under vigorous stirring until the red color disappeared (15-30 minutes). The reaction was then cooled and the mixture extracted with ethyl acetate. The organic phase was dried with Na2SO4, evaporated under vacuum and the product purified by crystallization with ethyl acetate or ethanol. (Pale yellow solid. Yield 45%).

Provenance & Evidence