HCID 69320502, compound → HCID 11313604, compound

Participants

Reaction Steps

7-Cyclopentyl-5-(6-nitro-1H-benzoimidazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (1E, 1.0 g) was combined with 10% Palladium on carbon (100 mg) in 50 mL of anhydrous NMP and subjected to 50 psi of hydrogen at room temperature for 24 hours. LCMS monitor suggested pure desired product (M/Z 333.5, retention time 0.70 min. with analytical HPLC method 4). The mixture was filtered through celite. Desired product was used as an NMP stock solution (concentration of about 0.92 g in 45 mL).

Provenance & Evidence