2-Chloroethylamine hydrochloride → HCID 21949759, compound

HRID 2114659Notes

Reaction equation

HRID 2114659 reaction equation
[CH:1]([C:4]1[C:8]([O:9][C:10]2[CH:11]=[C:12]([CH:15]=[C:16]([CH3:18])[CH:17]=2)[C:13]#[N:14])=[C:7]([CH3:19])[NH:6][N:5]=1)([CH3:3])[CH3:2].Cl.Cl[CH2:22][CH2:23][NH2:24]>>[NH3:5].[NH2:24][CH2:23][CH2:22][N:6]1[C:7]([CH3:19])=[C:8]([O:9][C:10]2[CH:11]=[C:12]([CH:15]=[C:16]([CH3:18])[CH:17]=2)[C:13]#[N:14])[C:4]([CH:1]([CH3:3])[CH3:2])=[N:5]1

Participants

4

Reactant 2

HCID 97937372-Chloroethylamine hydrochlorideHCID 21949895HCID 21949895, compound

Product 2

HCID 222AmmoniaHCID 21949759HCID 21949759, compoundYield 62.1%

Procedure

The pyrazole from Example 205 (70 mg, 0.27 mmol) and 2-chloroethylamine hydrochloride (38 mg, 0.33 mmol) were heated as a melt at 150° C. for 18 hours. The residue was cooled and purified by flash chromatography on silica gel eluting with dichloromethane:methanol:0.88 ammonia (95:5:0.5, by volume) to give the title compound (25 mg).

Workup

  1. temperatureThe residue was cooled
  2. custompurified by flash chromatography on silica gel eluting with dichloromethane

Sources & evidence

ORD record
ord-d2f30c583d7f4a3b990ab87a73fd980f
Source dataset
uspto-grants-2008_10
Patent number
US07435728B2

Reaction notes

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