HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → Dichloromethane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-Benzyloxyphenylacetyl Chloride | HCID 11357442 | — |
| Reactant | (4-Fluoro-phenyl)-[2-(3-methoxy-phenyl)-ethyl]-amine | HCID 23440722 | — |
| Product | Dichloromethane | HCID 6344 | 387.7% |
| Product | N-(4-Fluorophenyl)-N-{2-(3-methoxyphenyl)ethyl}-2-{4-(phenylmethoxy)phenyl}acetamide | HCID 23440755 | — |
Reaction Steps
The title compound was prepared as described in Example 1.C, using (4-fluorophenyl){2-(3-methoxyphenyl)ethyl}amine (14.2 g, 58 mmol) and 4-benzyloxyphenylacetyl chloride (15.1 g, 58 mmol) prepared from the corresponding carboxylic acid (14.0 g, 58 mmol) and oxalyl chloride (6.5 mL, 75 mmol) in CH2Cl2 (150 mL) (19.1 g, 70% yield): ES-MS (m/z) 470 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435729B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-68836073abaa447f8610c6f811036741 |
| Source note | uspto-grants-2008_10 |