HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → 2-(4-Acetamidophenyl)-1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 2-(4-Acetamidophenyl)-1-(4-hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline | HCID 23440786 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4-Acetamidophenyl)-1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-ol | HCID 9952243 | 75% |
Reaction Steps
A solution of 2-(4-acetamidophenyl)-1-(4-hydroxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline (0.025 g, 0.062 mmol) in 1 mL of CH2Cl2 was demethylated with BBr3 as described in Example 30.G to provide the title compound (0.018 g, 75% yield). ES-MS, (m/z) 389 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435729B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-a8b8254f892d4be5822b0bb236b0019d |
| Source note | uspto-grants-2008_10 |