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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2114726Generated: November 1, 2026

3-(4-Hydroxyphenyl)propionic acid → N-(4-Fluorophenyl)-3-(4-hydroxyphenyl)-N-{2-[3-(phenylmethoxy)phenyl]ethyl]propanamide

https://huagongshe.com/reaction/2114726

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-Hydroxyphenyl)propionic acidHCID 10394—
Reactant(4-Fluorophenyl){2-[3-(phenylmethoxy)phenyl]ethyl}amineHCID 23440828—
ProductN-(4-Fluorophenyl)-3-(4-hydroxyphenyl)-N-{2-[3-(phenylmethoxy)phenyl]ethyl]propanamideHCID 2344076889%

Reaction Steps

The title compound was prepared as described in Example 44.D using (4-fluorophenyl){2-[3-(phenylmethoxy)phenyl]ethyl}amine (1.4 g, 4.36 mmol) and 3-(4-hydroxyphenyl)propanoic acid (1.01 g, 6.11 mmol) to provide the title compound (1.82 g, 89% yield): ES-MS (m/z) 470 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07435729B2
Source datasetuspto-grants-2008_10
ORD IDord-b9d7b9866f7d49f49c4ea10de68e1ac3
Source noteuspto-grants-2008_10