Methanol → HCID 11632828, compound

Participants

Reaction Steps

Sodium borohydride (1.0 mg, 0.026 mmol), followed by MeOH (0.1 mL), was added to a solution of 4-{2-[(R)-2-oxo-6-((E)-3-oxo-4-phenyl-but-1-enyl)-piperidin-1-yl]-ethylsulfanyl}-butyric acid methyl ester (6.8 mg, 0.017 mmol) in CH2Cl2 (0.3 mL) at 0 ° C. After 15 min at 0° C., the reaction was quenched with aqueous HCl (0.1 M, 4 mL) and extracted with CH2Cl2 (3×5 mL). The combined organic phase was dried (Na2SO4), filtered and concentrated in vacuo to afford 6.8 mg (99%) of the title compound.

Provenance & Evidence