HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → tert-butyl-3-(N'-hydroxycarbamimidoyl)morpholine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | tert-Butyl 3-cyanomorpholine-4-carboxylate | HCID 21098190 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-butyl-3-(N'-hydroxycarbamimidoyl)morpholine-4-carboxylate | HCID 21098191 | — |
Reaction Steps
A solution of the product of Step 3 (1 eq.), hydroxylamine hydrochloride (1.4 eq.) and triethylamine (1.7 eq.) in EtOH (0.5 M) was refluxed under nitrogen for 5 hours. Mixture was concentrated and residues taken up in EtOAc and washed with water and brine. Combined organics were dried over Na2SO4 and evaporated giving the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435734B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-f24d70e8195a4c878714a8ef041262b6 |
| Source note | uspto-grants-2008_10 |