4-Fluorobenzylamine → HCID 54677508, compound

HRID 2114763Notes

Reaction equation

HRID 2114763 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH:9]1[C:14]1[N:15]([CH3:34])[C:16](=[O:33])[C:17]([O:24]C(=O)C2C=CC=CC=2)=[C:18]([C:20]([O:22]C)=O)[N:19]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:35][C:36]1[CH:43]=[CH:42][C:39]([CH2:40][NH2:41])=[CH:38][CH:37]=1>CO>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH:9]1[C:14]1[N:15]([CH3:34])[C:16](=[O:33])[C:17]([OH:24])=[C:18]([C:20]([NH:41][CH2:40][C:39]2[CH:42]=[CH:43][C:36]([F:35])=[CH:37][CH:38]=2)=[O:22])[N:19]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 673264-FluorobenzylamineHCID 21098188HCID 21098188, compound

Product 1

HCID 54677508HCID 54677508, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The methyl ester 8B in dry MeOH was treated with 4-fluorobenzylamine (2.5 eq.) at reflux for 2 hours. Solvent was removed in vacuo and residue triturated with Et2O to obtain the title product.

Workup

  1. temperatureat reflux for 2 hours
  2. customSolvent was removed in vacuo and residue
  3. customtriturated with Et2O

Sources & evidence

ORD record
ord-bdfb0bcbba724f7e92fa560c6208abc0
Source dataset
uspto-grants-2008_10
Patent number
US07435734B2

Reaction notes

Loading…