HCID 54702710, compound → HCID 54711995, compound

HRID 2114765Notes

Reaction equation

HRID 2114765 reaction equation
C([N:3]1[CH2:8][CH2:7][N:6]([CH3:9])[CH:5]([C:10]2[N:11]([CH3:29])[C:12](=[O:28])[C:13]([OH:27])=[C:14]([C:16]([NH:18][CH2:19][C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)=[O:17])[N:15]=2)[CH2:4]1)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[F:26][C:23]1[CH:24]=[CH:25][C:20]([CH2:19][NH:18][C:16]([C:14]2[N:15]=[C:10]([CH:5]3[CH2:4][NH:3][CH2:8][CH2:7][N:6]3[CH3:9])[N:11]([CH3:29])[C:12](=[O:28])[C:13]=2[OH:27])=[O:17])=[CH:21][CH:22]=1

Participants

3

Reactant 1

HCID 54702710HCID 54702710, compound

Product 1

HCID 54711995HCID 54711995, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

The crude product from Step 3 was stirred in CH2Cl2/TFA (1:1) for 2 hours to remove the Boc protective group from the piperazinyl nitrogen.

Workup

  1. customto remove the Boc protective group from the piperazinyl nitrogen

Sources & evidence

ORD record
ord-2d60676adf66434195955920d447f938
Source dataset
uspto-grants-2008_10
Patent number
US07435734B2

Reaction notes

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