Trifluoroacetic acid methylene chloride → HCID 17961816, compound

HRID 2114767Notes

Reaction equation

HRID 2114767 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:10]([O:11][C:12](=[O:19])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:9]([OH:20])[N:8]=[C:7]([CH:21]2[CH2:25][CH2:24][CH2:23][N:22]2C(OC(C)(C)C)=O)[N:6]=1)=[O:4].[C:33](O)(C(F)(F)F)=O.C(Cl)Cl>>[C:12]([O:11][C:10]1[C:9](=[O:20])[N:8]([CH3:33])[C:7]([CH:21]2[CH2:25][CH2:24][CH2:23][NH:22]2)=[N:6][C:5]=1[C:3]([O:2][CH3:1])=[O:4])(=[O:19])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 178499071HCID 178499071, compound

Product 1

HCID 17961816HCID 17961816, compound

Procedure

Methyl-5-(benzoyloxy)-2-[1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-6-hydroxypyrimidine-4-carboxylate was treated with TFA:CH2Cl2 (3:7) at 0° C. The solution was warmed to room temperature and the progress of the reaction was monitored by MS analysis. After 1 h the reaction was complete and the solvent was removed under reduced pressure using a rotatory evaporator. The title product was precipitated with Et2O and collected by filtration.

Workup

  1. customthe solvent was removed under reduced pressure
  2. customa rotatory evaporator
  3. customThe title product was precipitated with Et2O
  4. filtrationcollected by filtration

Sources & evidence

ORD record
ord-d025a901b13f41eb97f36de9ff48724e
Source dataset
uspto-grants-2008_10
Patent number
US07435734B2

Reaction notes

Loading…