HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2114771Generated: November 3, 2026
4-Fluorobenzylamine → n-(4-Fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-2-[1-(pyridin-2-ylcarbonyl)-1,2,3,4-tetrahydroquinolin-2-yl]-1,6-dihydropyrimidine-4-carboxamide
https://huagongshe.com/reaction/2114771
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Fluorobenzylamine | HCID 67326 | — |
| Reactant | Methyl 5-benzoyloxy-1-methyl-6-oxo-2-[1-(pyridin-2-ylcarbonyl)-1,2,3,4-tetrahydroquinolin-2-yl]-1,6-dihydropyrimidine-4-carboxylate | HCID 17961698 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | n-(4-Fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-2-[1-(pyridin-2-ylcarbonyl)-1,2,3,4-tetrahydroquinolin-2-yl]-1,6-dihydropyrimidine-4-carboxamide | HCID 54708375 | — |
Reaction Steps
The residue of Step 2 was dissolved in DMF and 4-fluorobenzylamine (3 eq.) was added. The reaction mixture was stirred at 90° C. for 1 H. The title compound was purified by preparative HPLC and isolated as its trifluoroacetic salt (C18, gradient of CH3CN/H2O+0.01% TFA).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07435734B2 |
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| Source dataset | uspto-grants-2008_10 |
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| ORD ID | ord-82e81941485e4d5f83cc3c7db8111569 |
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| Source note | uspto-grants-2008_10 |
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