4-Fluorobenzylamine → HCID 58786837, compound

HRID 2114772Notes

Reaction equation

HRID 2114772 reaction equation
[C:1]([N:9]1[CH2:13][C@H:12]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:11][C@H:10]1[C:22]1[N:23]([CH3:42])[C:24](=[O:41])[C:25]([O:32]C(=O)C2C=CC=CC=2)=[C:26]([C:28]([O:30]C)=O)[N:27]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:43][C:44]1[CH:51]=[CH:50][C:47]([CH2:48][NH2:49])=[CH:46][CH:45]=1>CO>[C:1]([N:9]1[CH2:13][C@H:12]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:11][C@H:10]1[C:22]1[N:23]([CH3:42])[C:24](=[O:41])[C:25]([OH:32])=[C:26]([C:28]([NH:49][CH2:48][C:47]2[CH:50]=[CH:51][C:44]([F:43])=[CH:45][CH:46]=2)=[O:30])[N:27]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 673264-FluorobenzylamineHCID 58786856HCID 58786856, compound

Product 1

HCID 58786837HCID 58786837, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound of Step 1 was dissolved in methanol and 4-fluorobenzylamine (5 eq.) was added. The mixture was refluxed overnight. After cooling, the reaction mixture was filtered and washed with ethyl ether to obtain the title product as a white solid.

Workup

  1. temperatureThe mixture was refluxed overnight
  2. temperatureAfter cooling
  3. filtrationthe reaction mixture was filtered
  4. washwashed with ethyl ether

Sources & evidence

ORD record
ord-48467add1b214532b68590066ee5f8ee
Source dataset
uspto-grants-2008_10
Patent number
US07435734B2

Reaction notes

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