Triethylamine → HCID 86628253, compound

Participants

Reaction Steps

In a similar manner to Step 1 of Example 233, 4-hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0287 g, 0.0622 mmol) was dissolved in acetonitrile (0.650 mL), and the solution was treated with triethylamine (0.0540 mL, 0.390 mmol) and 5-fluoro-2-methylbenzenesulfonyl chloride (0.0286 mL, 0.195 mmol) to obtain 4-(2-methyl-5-fluorobenzenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0157 g, yield 40%).

Provenance & Evidence