HCID 69148085, compound → HCID 69145692, compound

Participants

Reaction Steps

To a cold (0° C.) solution of tert-butyl 4-(3-chloro-4-fluorobenzyl)-3-oxopiperazine-1-carboxylate (3.3 g, 9.63 mmol) in ethyl acetate (150 mL), anhydrous hydrogen chloride gas was bubbled for ten minutes. The resultant solution was stirred at 0° C. for 1 hour, and concentrated under vacuum. The residue was treated with chloroform saturated with ammonia gas. The resultant white suspension was stirred at room temperature for 15 minutes and filtered through a pad of Celite. The filtrate was concentrated under vacuum. The residue was redissolved in benzene, filtered, and concentrated under vacuum to provide the title piperazinone as pale yellow viscous oil.

Provenance & Evidence