HCID 58857943, compound → HCID 54692333, compound

Participants

Reaction Steps

A mixture of 8-(4-fluorobenzyl)-10-benzyloxy-2,4-dimethyl-7,8-dihydropyrido-[3′,4′:4,5]pyrrolo[1,2-a]pyrazine-1,9(2H,6H)-dione (27 mg, 0.06 mmol) and Pearlman's catalyst (2.5 mg, 20% Pd(OH)2 on carbon) in ethanol (5 mL) was stirred under an atmosphere of hydrogen gas (1 atm) at room temperature for 1 hr. The reaction product precipitated out of solution. The suspension was treated with chloroform, and the mixture was filtered through a pad of Celite. The filtrate was concentrated under vacuum, and the residue recrystallized from ethanol to provide the title product.

Provenance & Evidence