4-Toluenesulfonyl chloride → HCID 86612117, compound

Participants

Reaction Steps

To a solution of 8-(4-fluorobenzyl)-10-hydroxy-3,4,7,8-tetrahydropyrido-[3′,4′:4,5]pyrrolo[1,2-a]pyrazine-1,9(2H,6H)-dione (1.0 g, 3.0 mmol) and triethylamine (0.64 mL, 4.6 mmol) in dichloromethane (30 mL), p-toluenesulfonyl chloride (0.64 g, 3.34 mmol) was added. The reaction mixture was stirred at rt overnight and concentrated under vacuum. The residue was subjected to reverse phase preparative HPLC purification. Collection and lyophilization of appropriate fractions provided the titled compounds.

Provenance & Evidence