Sodium Methoxide → HCID 54692348, compound

HRID 2114828Notes

Reaction equation

HRID 2114828 reaction equation
[F:1][C:2]1[CH:41]=[CH:40][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][N:10]3[C:13]4[CH2:30][CH2:29][N:28]([CH2:31][C:32]5[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=5)[C:27](=[O:38])[C:14]=4[C:15]([O:16]S(C4C(C)=CC=CC=4)(=O)=O)=[C:9]3[C:8]2=[O:39])=[CH:4][CH:3]=1.C[O-].[Na+]>CO>[F:1][C:2]1[CH:41]=[CH:40][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][N:10]3[C:13]4[CH2:30][CH2:29][N:28]([CH2:31][C:32]5[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=5)[C:27](=[O:38])[C:14]=4[C:15]([OH:16])=[C:9]3[C:8]2=[O:39])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 86612116HCID 86612116, compound

Product 1

HCID 54692348HCID 54692348, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 8-(4-fluorobenzyl)-2-(4-pyridinylmethyl)-10-toluenesulfonyloxy-3,4,7,8-tetrahydropyrido-[3′,4′:4,5]pyrrolo[1,2-a]pyrazine-1,9(2H,6H)-dione (10 mg, 0.017 mmol) and sodium methoxide (3 mg, 0.052 mmol) in anhydrous methanol (0.5 mL) was heated in an oil bath at 60° C. for one hour. The solution was subjected to reverse phase preparative HPLC purification. Collection and lyophilization of appropriate fractions provided the titled compounds.

Workup

  1. customphase preparative HPLC purification
  2. customCollection and lyophilization of appropriate fractions

Sources & evidence

ORD record
ord-16a773e9014948afbf0b98eaa04776f4
Source dataset
uspto-grants-2008_10
Patent number
US07435735B2

Reaction notes

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