Ethanol → HCID 54692355, compound

Participants

Reaction Steps

A mixture of 10-(benzyloxy)-2-(3-chloro-4-fluorobenzyl)-4,8-dimethyl-7,8-dihydropyrido-[3′,4′:4,5]pyrrolo[1,2-a]pyrazine-1,9(2H,6H)-dione (0.20 g, 0.40 mmol) and 5% Pd/C (40 mg) in a mixture ethanol (100 mL) and acetic acid (11 mL) was stirred under an atmosphere of hydrogen gas (1 atm) at room temperature for 1 hr. The reaction mixture was filtered through a pad of Celite. The filtrate was concentrated under vacuum, and the residue subjected to reverse phase HPLC purification. Collection and lyophilization of appropriate fractions provided the title product.

Provenance & Evidence