Hydrochloric Acid → HCID 69147888, compound

Participants

Reaction Steps

To a solution of tert-butyl 9-2,4-dimethoxybenzyl)-8-oxo-6,9-diazaspiro[4.5]decane-6-carboxylate (1.76 g, 4.36 mmol) in dioxane (34 mL) at 0° C. was added 4.0M HCl in dioxane (10.22 mL, 40.89 mmol). The reaction was stirred at room temperature for 4 days and treated with MP-carbonate resin (6.70 g, load value of 2.62 mmol/g) and Hunig's base (26 μL). The mixture was placed on a rotator for 2 days and filtered, washing with CH2Cl2. The resulting filtrate was concentrated in vacuo to afford the product as an orange oil.

Provenance & Evidence