HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 69148003, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | Methylamine hydrochloride | HCID 6364545 | — |
| Reactant | HCID 69147568 | HCID 69147568 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 69148003 | HCID 69148003 | — |
Reaction Steps
To a solution of N-[(benzyloxy)carbonyl]-N-(2-oxopropyl)glycine (2.29 g, 8.63 mmol) in CH2Cl2 (44 mL) were added a solution of methylamine hydrochloride (1.52 g, 22.45 mmol) and Et3N (3.13 mL, 22.45 mmol) in CH2Cl2, acetic acid (0.99 mL, 17.27 mmol), and sodium triacetoxyborohydride (5.12 g, 24.17 mmol). The suspension was stirred at room temperature overnight and concentrated in vacuo to afford the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435735B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-340acf07b1ca460180cdad6564a88ba0 |
| Source note | uspto-grants-2008_10 |