1,2-Dichloroethane → HCID 69148098, compound

Participants

Reaction Steps

A solution of N-[(benzyloxy)carbonyl]-N-[2-(methylamino)propyl]glycine (2.42 g, 8.63 mmol) in DMF (40 mL) was treated with EDC (1.66 g, 8.63 mmol) and stirred at room temperature overnight. The reaction was diluted with EtOAc and washed once each with aqueous 1N HCl, saturated aqueous NaHCO3, and brine. The combined aqueous layers were extracted once with EtOAc, and the combined organic layers were dried over Na2SO4, filtered, and concentrated in vacuo. The crude material was subjected to column chromatography eluting with a gradient of 50-100% EtOAc/hexanes. Collection and concentration of the appropriate fractions afforded the product.

Provenance & Evidence