tert-Butanol → HCID 69171435, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-(3-chloro-4-fluorobenzyl)-10-methoxy-8-methyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrido[3′,4′:4,5]pyrrolo[1,2-a]-pyrazine-4-carboxylic acid (0.74 g, 1.70 mmol), diisopropylethylamine (0.28 g, 2.13 mmol), and diphenylphosphoryl azide (0.57 g, 2.13 mmol) in mixture of 1,2-dichlorobenzene (10 mL) and anhydrous tert-butyl alcohol (10 mL) was heated in a sealed tube in an oil bath 120° C. for one hour. The reaction mixture was concentrated under vacuum. The residue was subjected to column chromatography on silica gel eluting with a methanol in ethyl acetate gradient. Collection and concentration of appropriate fractions provided the titled compound.

Provenance & Evidence