Trifluoroacetic acid → HCID 69173655, compound

Participants

Reaction Steps

A cold (0° C.) solution of 2-(3-chloro-4-fluorobenzyl)-10-methoxy-4-(N-tert-butoxylcarbonyl-N-methanesulfonyl-amino)-8-methyl-7,8-dihydropyrido-[3′,4′:4,5]pyrrolo[1,2-a]pyrazine-1,9(2H,6H)-dione (90 mg, 0.15 mmol) and trifluoroacetic acid (2 mL) in anhydrous dichloromethane (3 mL) was stirred for 3 hours. The product mixture was concentrated under vacuum. The residue was subjected to column chromatography on silica gel eluting with 20% methanol in ethyl acetate. Collection and concentration of appropriate fractions provided the titled compound.

Provenance & Evidence