Methyl iodide → HCID 69172682, compound

Participants

Reaction Conditions

Reaction Steps

A cold (0° C.) solution of 2-(3-chloro-4-fluorobenzyl)-10-methoxy-4-(N-tert-butoxylcarbonyl-amino)8-methyl-7,8-dihydropyrido-[3′,4′:4,5]pyrrolo[1,2-a]pyrazine-1,9(2H,6H)-dione (0.54 g, 1.07 mmol) in anhydrous DMF (6 mL) was treated with sodium hydride (38 mg, 1.60 mmol). The resultant mixture was stirred at the same temperature for 30 minutes, and treated with iodomethane (0.23 g, 1.60 mmol). After stirring at 0° C. for 1 hour, the product mixture was concentrated under vacuum. The residue was partitioned between chloroform and brine. The organic extract was dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum to provide the titled compound.

Provenance & Evidence