HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Fluoro-1-methylindoline-2,3-dione → 7-Fluoro-1-methylindolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Fluoro-1-methylindoline-2,3-dione | HCID 11845967 | — |
| Solvent | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Product | 7-Fluoro-1-methylindolin-2-one | HCID 11951674 | — |
Reaction Steps
7-Fluoro-1-methyl-1H-indole-2,3-dione (6, 2.48 g, 0.0138 mol) is heated with neat hydrazine hydrate (30 ml) at 130° C. for 30 minutes. The mixture is cooled, diluted with ice water and extracted with ethyl acetate. The extract is washed with brine, dried (Na2SO4), and evaporated to give the title compound as a solid. HPLC r.t. 4.07 min; MS for C9H8FNO m/z 165.16 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435751B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-fc5b0e397e1b4beabe3556877bc5b85f |
| Source note | uspto-grants-2008_10 |