HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → 2-chloro-N-(2-fluoro-4-nitrophenyl)-N-methylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | 2-fluoro-N-methyl-4-nitroaniline | HCID 11951847 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-chloro-N-(2-fluoro-4-nitrophenyl)-N-methylacetamide | HCID 11951848 | — |
Reaction Steps
Chloroacetyl chloride (1.87 ml, 0.0235 mol) is added to (2-fluoro-4-nitro-phenyl)-methyl-amine (14, 2.00 g, 0.0118 mol) in toluene (20 ml) and the mixture refluxed for 3 hours. The mixture is evaporated under vacuum and the residue triturated with ethanol to give the title compound as a white solid. HPLC r.t. 4.57 min; MS for C9H8ClFN2O3 m/z 247 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435751B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-d04273549bfb4216a8f25c238b15d52e |
| Source note | uspto-grants-2008_10 |