Ethanol → 3-(3-Bromo-thiophen-2-yl)-5-(4-chloro-phenyl)-[1,2,4]-oxadiazole

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Reaction Steps

3-Bromo-thiophene-2-amidoxime: The title compound was prepared from 3-bromo-2-cyano-thiophene (564 mg, 3.00 mmol) and 0.576 M hydroxylamine hydrochloride in 95% ethanol (5.8 μL, 3.3 mmol) similar to Example 36c, and yielded 383 mg (58%) of white solid. 1H NMR (Acetone-d6): 9.18 (s, 1H), 7.51 (d, J=5.50 Hz, 1H), 7.06 (d, J=5.22 Hz, 1H), 5.59 (s, 2H).

Provenance & Evidence