3-Chlorothiophene-2-carbonyl chloride → HCID 9901604, compound

HRID 2114928Notes

Reaction equation

HRID 2114928 reaction equation
[C:1]([NH:4][C:5]1[CH:14]=[CH:13][C:8]([C:9](=[N:11][OH:12])[NH2:10])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[Cl:15][C:16]1[CH:20]=[CH:19][S:18][C:17]=1[C:21](Cl)=O>>[C:1]([NH:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]2[N:10]=[C:21]([C:17]3[S:18][CH:19]=[CH:20][C:16]=3[Cl:15])[O:12][N:11]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 27358243-Chlorothiophene-2-carbonyl chlorideHCID 2806814HCID 2806814, compound

Product 1

HCID 9901604HCID 9901604, compound

Procedure

The title compound was prepared from 4-acetamidobenz amidoxime (55.4 mg, 0.287 mmol) and 3-chloro-thiophene-2-carbonyl chloride (52.4 mg, 0.289 mmol) similar to Example 16, and yielded 33.6 mg (37%) of light orange solid. 1H NMR (CDCl3): 8.12 (d, J=8.52 Hz, 2H), 7.66 (d, J=8.79 Hz, 2H), 7.60 (d, J=5.22 Hz, 1H), 7.35 (s, 1H), 7.12 (d, J=5.22 Hz, 1H).

Workup

  1. customyielded 33.6 mg (37%) of light orange solid

Sources & evidence

ORD record
ord-a00145c9c3d340fb852d0a4faea41ac9
Source dataset
uspto-grants-2008_10
Patent number
US07435750B2

Reaction notes

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