N'-hydroxy-3-(trifluoromethyl)benzimidamide → HCID 9923594, compound

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Reaction Steps

The title compound was prepared from 3-trifluoromethyl-benzamidoxime (70.3 mg, 0.344 mmol) and 3-chloro-thiophene-2-carbonyl chloride (62 mg, 0.343 mmol), similar to Example 16, and yielded 81.6 mg (72%) as an off-white solid. 1H NMR (CDCl3): 8.44 (s, 1H), 8.36 (d, J=7.69 Hz, 1H), 7.80 (d, J=8.51 Hz, 1H), 7.67 (d, J=7.96 Hz, 1H), 7.64 (d, J=5.21 Hz, 1H), 7.15 (d, J=5.22 Hz, 1H).

Provenance & Evidence