3-Pyridinecarbonyl chloride, hydrochloride (1:1) → HCID 22147877, compound

HRID 2114940Notes

Reaction equation

HRID 2114940 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH:9][NH:10][C:11](=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[N:14][CH:13]=1)=O.Cl.C(Cl)(=O)C1C=CC=NC=1>>[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[O:18][C:11]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[N:10][N:9]=1

Participants

3

Reactant 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 86587356HCID 86587356, compound

Product 1

HCID 22147877HCID 22147877, compound

Procedure

Nicotinic acid N′-(3-chloro-thiophene-2-carbonyl)-hydrazide: The title compound was prepared from 3-chloro-thiophene-2-carbonyl hydrazide (70 mg, 0.40 mmol) and nicotinoyl chloride hydrochloride (348 mg, 1.96 mmol) similar to Example 84b, and yielded 76 mg (68%) of white solid. 1H NMR (DMSO-d6): 10.82 (s, 1H), 10.33 (s, 1H), 9.07 (s, 1H), 8.79 (d, J=3.84 Hz, 1H), 8.26 (d, J=6.87 Hz, 1H), 7.93 (d, J=5.22 Hz, 1H), 7.58 (dd, J=7.55, 4.53 Hz, 1H), 7.23 (d, J=4.95 Hz, 1H).

Sources & evidence

ORD record
ord-209dbc25259d4a2bae24936bb70318df
Source dataset
uspto-grants-2008_10
Patent number
US07435750B2

Reaction notes

Loading…